Mendes, 47, insisted he would not be back for Bond 24 shortly after the release of the last film in the 007 film franchise as he is busy with some other project, reported Daily Star.
At the London premiere of his new theatrical reworking of Roald Dahl's 'Charlie and the Chocolate Factory', Mendes revealed he has not ruled out a return to the world of Bond.
Asked if he would be making the next Bond film, he said, "I don't know yet. I'm in discussions over the 'B' word (Bond), and I won't make a decision until this (Charlie and the Chocolate Factory) is open."
Cruz is married to Javier Bardem, who played villain Silva in 'Skyfall'.