"The stage is set but I'm excited for a meet cute at some point. I'm single and I'm excited about the future," Mayer,38 , said.
The singer has had his share of failed romances with a bevy of Hollywood beauties including Taylor Swift, Katy Perry, Jennifer Aniston, Jessica Simpson, Jennifer Love Hewitt and Minka Kelly.
"I'm ready to roll, I'm more mature than I've ever been," Mayer added.
The star appeared on Andy Cohen's show with his "Dead & Company" band mate Bob Weir. The pair surprised Cohen and the viewers with a surprise performance of the 1970 classic "Friend of the Devil.