The 'Thanks for Sharing' star, who has two children, Apple, nine, and Moses, eight, with her rocker husband Chris Martin, said she is too busy for it, reported Contactmusic.
"No! I have too much on my plate as it is!," she said.
Paltrow, 40, previously hinted that she would love to expand her family despite suffering a traumatic miscarriage a few years ago.
After revealing earlier this year that she had once lost a baby, she said she felt like she was missing a third child.