Speculation about a sequel was rampant in the months after "Bridesmaids" became one of the surprise hits of 2011, but both Jon Hamm and Chris O'Dowd have said a sequel is unlikely, reported Digital Spy online.
McCarthy appeared more positive about a potential "Bridesmaids 2" when questioned.
"I would do anything...If (co-writers) Kristen (Wiig) and Annie (Mumolo) wrote something, if it was like, on the back of a napkin and they wanted me to perform it in the backyard, I would do it," McCarthy said.
"I'll let those ladies decide if we're doing a sequel."
Wiig said in early 2012 that she had no plans to write "Bridesmaids 2", although she stopped short of ruling out the idea entirely.
"Bridesmaids" has earned over 183.4 million pounds at the worldwide box office, and garnered Wiig and Mumolo a 'Best Writing (Original Screenplay) Oscar nomination.
McCarthy also received an Oscar nod in the 'Best Supporting Actress' category.