The 37-year-old flame-haired actress, who plays Joan Holloway in the 60s-set TV show, which was recently renewed for a sixth season.
She said that the programme has completely changed her career and she doubts she will ever find a job she loves as much, reported Sun online.
"It's completely changed my career. Instead of people wondering who you are, you walk in and they say, 'I love your show'. It's a nice way to start an audition. I hate to think of it ever finishing. I have concerns about finding something I'm going to fall in love with as much," Hendricks said.
However, the actress, who is married to actor Geoffrey Arend, is looking forward to other projects and spending some time with her husband.
"I've got a couple of things lined up for the next break, and I hope to enjoy my home and husband," she added.