The 41-year-old actress said the key to success is not feeling sorry for yourself when things don't go as planned, reported E! online.
"I remember losing auditions or being let go from a job and I'd say, 'That must mean there's something amazing ahead for me!' My friends would laugh and look at me like I was crazy. I have never, ever had a personal pity party," Longoria said.
The "Desperate Housewives" star said she did not always have it easy, but that never stopped her from working hard to earn what she wanted.
"There was never any resentment, because I saw how hard my mother worked and all she did for my sister (with special needs), and I wanted to do whatever I could to help. We all did.
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