The hosts go into the game after a 1-1 draw against another Goan side, Sporting Clube de Goa.
Arthur Papas-guided Dempo, striving to retain the crown they last won three seasons ago, are going into the game after a 0-3 home loss against Shillong Lajong.
For Mumbai FC, medio Climax Lawrence and defender Valeriano Rebello will be up against their former team for the first time since joining the club.
The backline will be led by the central defencive duo of Haroon Amiri and Anwar Ali. Both of them have now started to gel and coach Khalid Jamil expects them to forge a strong partnership.
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"My attack wasn't up to the mark in the previous game, but the defence under the leadership of Amiri and Anwar was excellent. Tomorrow is a big match and we can only get better and improve from here," said Jamil ahead of the game.
Dempo have also added India internationals, striker Jeje Lalpekhlua and medio Jewel Raja Shaikh to their squad while former Mumbai FC forward Gabriel Fernandes will be up against his old team for the first time.
Mumbai FC have never won a game against Dempo in twelve encounters so far in all the competitions and coach Jamil is hopeful things will change tomorrow.