"I want to run for president and I'm quite frank about it," the veteran democracy activist said at a session at the World Economic Forum (WEF) being held here.
"If I pretend I did not want to be president, I would not be honest and I would rather be honest with my people than otherwise.
"You really don't run for the President because President is not elected directly, but for me to be eligible for the post of the President the Constitution will have to be amended," the 67-year-old said.
The session themed 'Myanmar: What Future?' also saw participation of Union Minister, Office of the President of Myanmar Soe Thane.
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Thane was of the view that amending the constitution is always possible, although Suu Kyi described the document passed in 2008 as "the most difficult constitution in the world to amend".
Suu Kyi's two sons with her late husband Michael Aris are British and the clause is widely believed to be targeted at the Nobel laureate, who was educated in India.