The 63-year-old star said she has no regrets about not having children of her own, reported Female First.
"I didn't want babies. I wouldn't have been a good mom for babies. I don't have the patience. I have the patience for puppies, but that's a quick stage!" Winfrey said.
The veteran talk show host said she hasn't missed out on being a parent because she is a mother figure to the 172 girls at her Leadership Academy boarding school in Johannesburg, South Africa.
"Love knows no boundaries. It doesn't matter if a child came from your womb or if you found that person at age two, 10 or 20. If the love is real, the caring is pure and it comes from a good space, it works," she said.