It will be an opportunity for the best performing players to then trial for the Caribbean Premier League (CPL).
The Combine will have two phases, with Phase 1 being an open trial. All eligible players in the Americas region can apply online by clicking here for the opportunity to be selected to attend the trial that will take place at the World Sports Park in Indianapolis from 18 to 21 September.
Some players identified through previous ICC Americas events will be invited to attend Phase 2 automatically.
"It's exciting that the ICC, in cooperation with the WICB, is able to provide this opportunity to the best cricketers in the Americas region," ICC's Head of Global Development, Tim Anderson, said in a release.
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"The region is full of talented cricketers, with many in the USA and Canada, and through the innovative open trial we hope to uncover some stars of the future."
Applications for Phase 1 of the Combine close on Friday July 17.
The ICC Americas region is part of the ICC's Development Programme, which aims to grow and improve cricket with ICC's 95 Associate and Affiliate Member countries.