"As the report... Clearly shows, there is much work to be done to confront the many harms inflicted by drugs, to health, development, peace and security, in all regions of the world," UNODC head Yury Fedotov said.
Around 29.5 million people worldwide, or 0.6 per cent of the adult population, suffered from drug use disorders in 2015, with at least 190,000 mostly avoidable deaths annually, mostly from opioids.
In 2016, global production of opium - extracted from poppy resin and refined to make heroin - rocketed by a third, mostly due to bumper harvests in Afghanistan, the report said, providing Taliban insurgents with millions of dollars.
Following a long-term decline, cultivation of coca - the raw material for cocaine - shot up 30 per cent over 2013-15, mainly due to Colombia, the world's biggest producer.
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But opioids, which include heroin, prescription painkillers like fentanyl and illegal counterfeits, remain by far the "most harmful" drugs in health terms, the UNODC said.
In the United States, gripped by an opioid epidemic, overdose deaths, most of them from opioids, more than tripled from 16,849 in 1999 to 52,404 in 2015, the report said.