Reham's degree in Broadcast Journalism which she said was from North Lindsey College was fake as the college never offered this course nor a student of her name was ever registered with it, the Express Tribune quoted the daily as saying.
"Reham Khan has not been truthful about her qualification," Daily Mail was quoted as saying by the newspaper.
Daily Mail is the same paper which broke the news of her marriage with Imran Khan at the start of the year.
"This morning is a great example of why I have never picked up the Daily Mail and why I don't watch Pakistani TV channels," Reham tweeted.
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But, later she had to issues clarifications and change the profile on her website where she initially claimed earning the degree in Broadcast Journalism from North Lindsey College.
In a clear volte-face, Reham said she never claimed to have a "degree in broadcast journalism" but she did a "diploma in broadcast media" from the Grimsby Institute Media Centre.
She also termed the story of Daily Mail as "malicious and baseless" which according to her was planted by her opponents.