Khan said the killing of Tehrik-e-Taliban chief Hakimullah Mehsud in a US drone strike before peace talks could begin was proof that the Americans did not want peace in the country.
The Khyber Pakhtunkhwa government is headed by Khan's Pakistan Tehreek-i-Insaf party and one of the two routes on which the NATO supplies reach Afghanistan passes through the province.
Speaking in the National Assembly, Khan warned the US to stop bombing Pakistani land through its unmanned planes' campaign and vowed to block the routes from November 20 "if government fails to pursue America to end drone strikes."
The session of the lower house of the Parliament, which commenced after a delay of two-and-a-half hour, was reserved for the debate, setting aside the routine agenda items.
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Imran, who is a strong opponent of US drone strikes in tribal areas of Pakistan urged political leaders to unite on the matter.
Despite all political differences, Khan said he was ready to reconcile with Jamiat Ulema-e-Islam chief chief Maulana Fazlur Rehman.
He again termed the US drone attack, that killed the TTP leader "a conspiracy to derail peace process."
The Minister, however, vowed to continue with efforts for holding peace talks with the Taliban.
"This would only be possible after the militant outfit chooses a new chief," he said.