The series will be the first five-match affair on Indian soil in three decades and the opening clash will also mark the debut of Rajkot as a Test venue.
It promises to be an engrossing contest between the world No.1 ranked India and the team that last beat them at home four years ago.
In 2012, England came back from a game down to turn the tables on India and post a 2-1 win in a four-game rubber.
Also some excellent batting by current skipper Alastair Cook and the controversial Kevin Pietersen, who is no longer a part of England's scheme of things, were the highlights for England.
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The current Indian team led by Virat Kohli, who was a member of the team that was vanquished four years ago and later in England (3-1) two years ago in a best-of-five contest, would not have forgotten the hard lessons.
This time around, however, England have come into the series after a first-ever shock defeat in a Test match at the hands of Bangladesh in Dhaka to draw the two-match rubber 1-1.
Both Cook and all-rounder Stuart Broad, who is to play his 100th Test, have talked about England being the clear "underdogs" going into the rubber, especially against an Indian side being led in aggressive style by Kohli.
Kohli would be extremely keen to improve his not-so-impressive record with the bat against the visitors.
Yesterday, vice captain Ajinkya Rahane talked about the dangers of becoming complacent even against an England side, which has a few new faces.
This would also be the first Test series in India where the Decision Review System (DRS), which the BCCI has consistently opposed, will be used.
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Rahane is a quality player and Kohli is known to back players to the hilt on whose abilities he has complete belief.
With the world's premier off-spinner Ravichandran Ashwin two short of becoming the fastest ever to reach 250 wickets and the deadly accurate Ravindra Jadeja for company, the likes of Tamim Iqbal, Soumya Sarkar or Mahmuddlah Riyadh won't exactly find any easy pickings.
In fact, the last time in Fatullah none of the Bangladeshi batsmen were able to read Ashwin. Not to forget the lively pace of Umesh Yadav and disconcerting bounce generated by Ishant Sharma.
The interesting part about India's home Tests this season has been that whether it is by choice or design, Kohli have had to change his playing XI most of the times.
His replacement Kuldeep Yadav is an exciting prospect but may have to wait a little longer to get a Test cap. Jayant Yadav, whose steady off-spin and good technique with the willow impressed one and all, is expected to get his place back.
Ishant and Umesh are certainly first choice new ball bowlers even though Bhuvneshwar Kumar, in limited chances, has done his case no harm.
In case, Kohli fancies the option of picking Pandya, checking him out before the big-ticket series against Australia, it could be in the place vacated by Mishra.
For Kohli and his boys, the Test gives them an ideal opportunity to break a few more records against a bowling attack whose only quality international level bowler is Shakib Al Hasan.
Kohli, who has been in rich vein of form in Test cricket, will not mind a substantial score against the likes of Mehdi Hasan Miraz, Shafiul Islam and Taskin Ahmed.
Ditto for KL Rahul, who would like to carry forward from his 199 in the final Test against England in Chennai. Murali Vijay will also be itching to bat against a bowling attack against which he had feasted on the last time, making 150. Not to forget that Vijay has a special fondness for this particular venue.