In a scene that would have been unimaginable just a few years ago, the former general will meet with President Barack Obama and later speak to leaders of US businesses eager to invest in a country that was long a Western pariah.
Critics say that President Barack Obama's invitation was premature and takes pressure off Myanmar to address still-alarming abuses such as recent anti-Muslim violence to which security forces allegedly turned a blind eye.
Obama -- whose 2009 inaugural speech pledge to reach out to US foes yielded limited results in the Middle East -- has been enthusiastic about Myanmar. He visited in November and has suspended most sanctions in recognition of changes.
The White House said in a statement that Thein Sein's visit "underscores President Obama's commitment to supporting and assisting those governments that make the important decision to embrace reform.