The nuclear pact was signed following a meeting between Prime Minister Narendra Modi and his Australian counterpart Tony Abbott during which the two leaders deliberated on crucial bilateral, regional and international issues including the situation in Iraq, Afghanistan and Ukraine.
Welcoming signing of the agreement, Modi said it was a "historic milestone" in bilateral relationship.
Australia has about a third of the world's recoverable uranium resources and exports nearly 7,000 tonnes of it a year. India and Australia had launched talks on uranium sales in 2012 after Canberra lifted a long-time ban on exporting the valuable yellow cake to Delhi to meet its ambitious nuclear energy programme.
"Australia can play the role of a long-term reliable supplies of uranium to India. It provides for supply of uranium, production of radio isotopes, nuclear safety and other areas of cooperation," as per the pact details.