Despite a century by skipper Mignon du Preez, South African eves failed to topple India's first innings total of 400 for six declared, thereby trailing the hosts by 166 runs.
As a rule, a team bowling out the opposition by keeping a cushion of 150 or more runs is entitled to enforce a follow-on and Indian skipper Mithali Raj decided to put South Africa in to bat again.
Apart from Preez, who scored a 253-ball 102 studded with 15 boundaries, only two other batters could reach the double-digit mark in the first innings.
While Trisha Chetty hit 56, opener Nadine Moodley had scored 40 yesterday.
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In their second innings, South Africa eves kept losing wickets at regular intervals and at the end of the day were staring at a comprehensive defeat.
At stumps, Chetty was unbeaten on six, while Chloe Tryon was not out on 15, still needing 83 runs to avoid an innings defeat.
India Women 1st innings: 400 for six decl
South Africa Women 1st innings: 234 all out in 110 overs (Mignon du Preez 102, Trisha Chetty 56; Harmanpreet Kaur 5/44, Rajeshwari Gayakwad 4/54).
South Africa Women 2nd innings: 83 for six 41 overs (Marizanne Kapp 19; Poonam Yadav 2/15, Jhulan Goswami 2/18).