The holdings crossed the $100 billion-mark in February, the highest level in more than a year, as per the latest data available with the Treasury Department.
In January also, India's holding had hit a one-year high of $91.2 billion.
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Since Prime Minister Narendra Modi-led government came to the power in May last year, the country's exposure to such securities have been on the rise. In May last year, the holding stood at $70.1 billion.
In February, Japan emerged as the largest holder of American government securities pushing China to second place.
Japan's holding stood at $1.224 trillion while that of China touched $1.223 trillion.
Among the BRIC nations, India is the third-largest holder of these securities after China and Brazil ($259.9 billion). Russia's exposure declined to $69.6 billion in February.
In the first three months of this year, US economy unexpectedly witnessed slower growth with the GDP expanding just 0.2%.
"Real gross domestic product -- the value of the production of goods and services in the US, adjusted for price changes -- increased at an annual rate of 0.2% in the first quarter of 2015," the Bureau of Economic Analysis' advance estimated released on April 29 said.
In the 2014 fourth quarter, real GDP had increased 2.2%.