"...Any high level participation or engagement from the Indian side in the CHOGM will not only embolden the Sri Lankan regime but also incense public opinion and sentiment in Tamil Nadu on this every sensitive issue even further", she said in a strongly-worded letter to Prime Minister Manmohan Singh.
She cited reports that Canada was likely to boycott and the House of Commons Committee on Foreign Affairs in the UK had also urged the British Prime Minister not to attend.
"As an emerging great power and an aspirant for a permanent seat in the UN Security Council, India has a duty to ensure that the values of democracy and respect for human rights are upheld anywhere in the world and in particular in its neighbourhood", the AIADMK supremo said.
As a leader in South Asia, India was uniquely positioned to exert the maximum influence on the Sri Lankans to accept an independent international mechanism to hold those who committed "genocide and war crimes" to account, she said.
Observing that there was still time to consider an alternative venue to hold the event and India should ask for it, Jayalalithaa said, "If India takes this diplomatic initiative, there is likely to be broad based support amongst member countries of the Commonwealth".
Accusing India of voting in favour of a "diluted and weak" US resolution against Sri Lanka and not moving any amendments at the UNHRC, she said, "There was widespread disappointment at this stand of the Government of India and a continuing sense of injustice in Tamil Nadu on this issue".