The Men in Blue won the first T20I at Johannesburg by 28 runs and a victory tomorrow will see them wrap up another series win on this tour.
A highly competitive 1-2 loss in the Tests, followed by a comprehensive 5-1 ODI triumph has made for quite a roller-coaster tour so far and the Indians would be aiming for a happy end to the long sojourn with a T20 victory.
Word from the Indian camp is that Virat Kohli will be fit in time for game. The skipper had hobbled off in latter stages of the previous game on Sunday with a left hip problem. The team management had deemed the issue as "nothing serious", and as such, he is expected to walk out at toss time on tomorrow.
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Wrapping up the series here might also enable Kohli to take time off and sit out the final T20I in Cape Town, keeping in mind his hectic schedule over the next three months.
If at all, India do need to consider his absence from this second match, then K L Rahhul would come in as replacement.
He was left out from the previous game in favour of Manish Pandey, but now comes back into reckoning owing to Kohli's pending fitness ruling.
The pitch at Supersport Park has played slow throughout this tour and the same is to be expected once more. In that light, India could once again opt for two spinners in the eleven, and 'chinaman' Kuldeep Yadav comes back into reckoning.
Even left-arm spinner Axar Patel, who hasn't got a game on tour yet, could be considered given his ability to keep things tight.
In Johannesburg, it was obvious that the team management had gauged conditions early and deemed 200 a par-score on that pitch.
Thus, their move to send Raina up and attack during the powerplay overs with Kohli held back to anchor the middle-order, allowing the returning left-hander a license to free shot-making.
To an extent, it does shore up India's only frailty lower middle order particularly as the team management continues to back MS Dhoni in the shortest format.
Kohli's 'demotion' to number four, despite staggering average at his favoured spot, helps stabilise the lower middle order at least in the short term.
Meanwhile, only last Tuesday, South Africa had faced a do-or-die moment in Port Elizabeth and now have their backs up against the wall for a second time in eight days.
The hosts had put their hopes in a basket full of new eggs. Yet, despite hitting the refresh button, they weren't able to muster the required challenge for a high-flying Indian team at the moment.
The stand-in skipper was adamant that their plans at Wanderers including the decision to bowl short to India's top-order in the powerplay overs were sound enough, and just needed proper execution.
In that light, it is easy to assume the same playing eleven could take the field yet again.
It remains to be seen if the Centurion pitch will provide them enough bounce to try out the short-ball ploy once again, or indeed if the Proteas have thought of a plan B this time around.
India: Virat Kohli (capt), Shikhar Dhawan, Rohit Sharma, Suresh Raina, Shreyas Iyer, Manish Pandey, Dinesh Karthik, MS Dhoni (wk), Hardik Pandya, Yuzvendra Chahal, Kuldeep Yadav, Axar Patel, Bhuvneshwar Kumar, Jasprit Bumrah, Jaydev Unadkat, Shardul Thakur.
South Africa: JP Duminy (capt), Farhaan Behardien, Junior Dala, Reeza Hendricks, Christiaan Jonker, Heinrich Klaasen (wk), David Miller, Chris Morris, Dane Paterson, Aaron Phangiso, Andile Phehlukwayo, Tabraiz Shamsi, Jon-Jon Smuts.
Match starts at: 9.30 pm IST.