Pradhan made the comments after Government Accountability Office (GAO) of US named Oil and Natural Gas Corp (ONGC), Indian Oil Corp (IOC) and Oil India Ltd (OIL) along with two Chinese firms for having energy ties with Iran, an act for which it can impose sanctions against them.
"India will take its own stand, independent diplomatic stand on the issue," he said. "Certainly economic interest of our companies and country will be priority."
The US Iran Sanctions Act provides for steps against persons, including foreign firms, investing more than USD 20 million in Iran's energy sector in any 12-month period.
According to GAO, the US has not imposed sanctions on any firm for their Iran energy ties since 1998.
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The US and its allies have pursued the sanctions route to isolate Iran over its alleged nuclear programme.
The three firms have been named for their stake in the Farsi offshore block in Iran.
"Looking at the diplomatic complexity of the whole issue, we will look at ways how our companies wont be affected by any adverse situation," Pradhan said.
All the three firms gave similar response to US GAO saying the "exploration contract (for Farsi block) expired in 2009" and that they had "not carried out any activity after 2007 in the Farsi Block".
OVL, IOC and OIL explored for oil and gas in Iran's Farsi block and proposed investing USD 5.5 billion to produce gas from the 21.68 trillion cubic foot discovery they made in the offshore area located near the Saudi Arabian border.