"I'm sharing with you that I'm launching my campaign to represent the people of California in the United States Senate. I want to be a voice for Californians," 50-year-old Harris announced yesterday in a message to her supporters posted on her campaign website.
"I will be a fighter for the next generation on the critical issues facing our country. I will be a fighter for middle class families who are feeling the pinch of stagnant wages and diminishing opportunity," she said.
If elected Harris, 50, would be the first ever Indian- American elected to the US Senate.
Born to an Indian mother, Dr Shyamala Gopalan, who emigrated from Chennai in 60s, and Jamaican American father, Stanford University economics professor Donald Harris, Harris is the first ever Asian-American and African-American to be elected to this top position in California.
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Many potential contenders have expressed interest in the post including former Los Angeles Mayor Antonio Villaraigosa and billionaire climate change activist Tom Steyer, as well as several members of the California congressional delegation.
But Harris's strong fundraising base in California from her two statewide runs and her close alliance with President Barack Obama, make her one of the most formidable candidates in the race.
Political pundits said Harris is a front-runner.
"Announcing so fast was a very shrewd move because it could keep other candidates out of the race," he said.