Anita Ashok Datar, 41, is the sole US citizen to have been killed in the attack yesterday, State Department Spokesman John Kirby said.
"We mourn American Anita Datar and all those lost in Mali Attacks," US Secretary of State John Kerry said in a tweet yesterday.
"We extend condolences to family & friends and stand with the Malian people," he said.
In a statement released through the US State Department, Datar's her family said that they are devastated by the news.
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Anita lived in Takoma Park in Maryland, a suburb of Washington DC.
"Anita was one of the kindest and most generous people we know. She loved her family and her work tremendously," the statement said.
"Everything she did in her life she did to help others- as a mother, public health expert, daughter, sister and friend," it said.
Datar was born in western Massachusetts and grew up in northern New Jersey.
She earned an MPH and MPA from Columbia University's Joseph Mailman School of Public Health and School of International and Public Affairs.
She was a senior manager at Palladium Group and a founding member of Tulalens, a not-for-profit organisation connecting underserved communities with quality health services.
Armed extremists stormed Radisson Blu hotel in Mali's capital town locking in 170 people, killing at least 27 of them. Twenty captured Indians were evacuated without any harm.