The Indian-Americans -- Manu Prakash and Subhash Khot are alumunus of Indian Institiute of Technology (IIT) in Kanpur and Bombay respectively.
Prakash works as an Assistant Professor in Department of Bioengineering at the Stanford University, while Khot is a theoretical computer scientist at the New York University.
The MacArthur fellowships, popularly known as "genius grants," are awarded to scholars who show exceptional creativity in their work and the prospect for still more in the future.
It includes a stipend of USD 625,000, given over five years, designed to provide the recipients the flexibility to pursue their activities in absence of specific obligations.
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"Manu Prakash is not only one of the most innovative scientists of our day, he is also using his interdisciplinary expertise to improve human health around the world," Stanford President Marc Tessier-Lavigne said.
He said the scientist harnesses a wide array of technologies, including optical physics, computer science, fluid dynamics, biology and chemistry, to solve tangible human and scientific problems.
The Stanford University, in a release said many of Prakash's ideas come from his travels and from his childhood growing up in India.
"Being in the field gives meaning to working in global health. It teaches you empathy, a driving force so strong that it transforms ideas into actions," Prakash said.
Khot is a theoretical computer scientist whose work is provides critical insight into unresolved problems in the field of computational complexity.
His continued ingenuity and tenacity in exploring the potential of the UGC will drive this important and fruitful area of research for many years to come, the MacArthur Foundation said in a statement.
Sri Lankan-American Ahilan Arulanantham is the third South Asian to bag this prestigious award.
He is an attorney working to secure the right to due process for individuals facing deportation.
Through advocacy and successful litigation of a series of landmark cases, Arulanantham has expanded immigrant detainees' access to legal representation and limited the government's power to detain them indefinitely, the Foundation said.
In an interview, Arulanantham said he would donate his USD 625,000 prize for the welfare immigrant children.
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