Chandigarh-born Srinivasan, 46, was sworn in at an overflowing court room of US Courts of Appeal for the District of Columbia Circuit by Justice Sandra Day O'Connor, in presence of legal luminaries, family and friends, including Prime Minister Manmohan Singh's wife Gursharan Kaur.
Kaur, literally drove off directly from the airport, with a brief stopover at the hotel, to be in time for the swearing in ceremony of the Indian-American.
It was in May this year that Srinivasan was confirmed by the US Senate by a huge 97-0 vote.
Srinivasan, whose parents migrated to the US in 1970s, is the first South Asian-American to serve as a circuit court judge in American history.
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The retired Supreme Court justice O'Connor described Srinivasan "fair, faultless and fabulous." He once clerked for her.
Addressing the gathering, Srinivasan acknowledged the contribution of his parents and family on his achievements.
Srinivasan was first nominated by US President Barack Obama on June 11, 2012.
Srinivasan's appointment is a testimony to his credibility and calibre as a brilliant legal luminary of the US. He was previously the Principal Deputy Solicitor General of the US.
Srinivasan is a highly-respected appellate advocate who has spent a distinguished career litigating before the US Supreme Court and the US Courts of Appeals, both on behalf of the US and in private practice.
Born in India to Indian parents, Srikanth "Sri" Srinivasan's well-deserved rise to the top echelons of the American judiciary - the first by an Indian-American to such a position - is a matter of great pride and satisfaction for India and the Indian-American community.
Srinivasan began his legal career by serving as a law clerk for Judge J Harvie Wilkinson on the US Court of Appeals for the Fourth Circuit from 1995 to 1996.