In the first round matches of the main draw, eighth seeded Karol Beck of Slovakia scored a comfortable 6-1 6-3 win over Yuki, while Russia's Igor Kunitsyn beat Vishnu 6-3 6-4, and in a battle of qualifiers, Oleksandr Nedovyesov outplayed Sanam 6-0 6-4 here at the Olympic Tennis School.
India's lone pair in the doubles event, Yuki and Divij also went down fighting to third seeded German pair of Andre Begemann and Martin Emmrich in the first round.
The German pair won 6-4 6-4, ending India's challenge at the event.
Meanwhile, in the first upset, local wild card Farrukh Dustov beat sixth seeded Vasek Pospisil of Canada 6-2 3-6 6-3 to enter the last sixteen stage.
Results (1st round singles): Lukas Lacko (SVK) b Ivan Sergeev (UKR) 6-2 6-3, Flavio Cipolla (ITA) b Sergey Shipilov (UZB) 6-1 4-6 6-0, Karol Beck (SVK) b Yuki Bhambri (IND) 6-1 6-3, Ivan Dodig (CRO) b Ivo Minar (CZE) 6-2 6-4, Dmitry Tursunov (RUS) b Daniel Munoz