Jayalalithaa, an actress-turned-politician, hospitalised since September 22, suffered a cardiac arrest on Sunday and passed away late last night in Chennai at the age of 68.
Taking to Twitter, the stars expressed their grief over the passing away of the politician.
"Not just Tamil Nadu but entire India is suffering because of the loss of its brave daughter. I pray to Almighty for our beloved CM's soul to rest in peace," Rajinikanth tweeted.
SRK tweeted, "Sad to hear of the passing away of Jayalalithaaji... May her soul rest in peace."
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Calling Jayalalithaa, people's leader, veteran actor Anupam Kher tweeted, "Deeply saddened by the passing away of the charismatic leader of the masses Jayalalitha ji. May God rest her soul in peace."
Oscar-winner Rahman wrote, "Respect and condolences to all the people who love Puratchi Thalaivi Jayalalitha... We will miss her forever."
Tamil star Ajith Kumar remembered Jayalalithaa as a charismatic leader.
"Rest in peace madam, one of our most charismatic, bold and brave leader in Indian political history ever!!," he wrote.
Veteran actor Dharmendra, who worked with Jayalalithaa in "Izzat", her debut in Hindi cinema, said he was shocked to hear the news of her passing away.
"It is shocking for me because she was my co-star in 'Izzat' in 1968. We were on outdoors together for almost one and a half months in Kulu-Manali. Those were good times. She was a lovely person and very cordial. She often cooked south Indian food for me. She was a great human being," Dharmendra said.
"V upset to hear abt Jayalalitha's passing away. She was strong,had tremendous will power & carved a special niche for herself in politics.
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Actors Randeep Hooda and Shruti Haasan also took to micro-blogging site to share they condolences.
"An actor who did so many real things that affected so many people. A real woman in the time of #feminism #RIPAmma," Hooda wrote.
While, Shruti tweeted, "TN loses one of its greatest leaders and bravest women- deeply saddened by this great loss - words cannot express."
Dhanush said Jayalalithaa's death leaves a vacuum in politics.
"#RIPAmma. The end of THE most inspirational era of Tamilnadu Politics. You leave behind a vast vacuum. #IronLady. #Shattered #empty #darkday," he tweeted.
"TN looses one of its greatest and boldest woman leaders who ruled the cinema industry and politics as well!and end of an iconic era!#RIPAmma," wrote Priyamani.
"Rang De Basanti" actor Sidharth said her demise was the end of an era.
Actress Gautami said, "Heartbroken at Amma's passing. A great lady who led us wth strength, vision, compassion n love. You left us too soon amma RIP #Jayalalithaa."
R Madhavan remembered the leader as a dynamic and powerful leader.