Niluji Adhikary, 35, a resident of Kolkata, died on the spot in Rapti Sunari Rural Municipality-9, about 500 kms west of Kathmandu, Himalayan Times reported.
The bus, heading towards Surkhet from Butwal, turned turtle at Dhakeri area in the wee hours, Deputy Superintendent of Police Suresh Kafle said.
All the injured were rushed to a nearby hospital.
Most of the passengers were Indian labourers who travel to Nepal on a daily basis for work, police said.