The car crash occurred when the family members were on their way back to home after visiting a church in Dubai.
CD Sunny, 46, had been working as a sales executive in Dubai for 24 years, Gulf News quoted the victims' family friends as saying.
"Apparently a 4WD car banged their car from behind when they reached Muhaisna," said Praveen Jose, a neighbour of Sunny's family from Kecheri in Kerala.
Sunny's wife Jolly and second son Edwin, four, have been admitted to Rashid Hospital.
"Edwin has fractured his leg... Jolly is completely shattered and is under sedation. The neighbour said Sunny's family used to live in Dubai earlier. They relocated to Kerala a few years ago.
"The wife and children had come here on a visit due to school vacation in India. They came on April 23 and were scheduled to fly back on this 28th," Jose added.