Yashika Bageerathi was to be taken from Yarl's Wood Immigration Removal Centre in Bedfordshire to the airport for an Air Mauritius flight.
A spokesperson for the Oasis Academy Hadley in north London, where Bageerathi has been studying, confirmed that the student had lost her appeal to stay in the UK.
This will be the third attempt to send her back to Mauritius in little over a week.
She was supposed to have gone on Sunday, but her supporters said Air Mauritius refused to fly her out, following an earlier refusal by British Airways.
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Immigration minister James Brokenshire told the House of Commons that her case had been through the proper legal process and the Home Office's decision that she did not need protection from violence or persecution in her homeland had been upheld.
Bageerathi has been held at Yarl's Wood immigration removal centre near Bedford since March 19.
She came to the UK with her mother, sister and brother in 2011 to escape a relative who was physically abusive and they claimed asylum last summer. But the family were told they all faced the threat of deportation.
A petition calling on authorities to stop the deportation has gathered more than 175,000 signatures.
Shadow immigration minister David Burrowes, who has campaigned for the Home Office to review its decision, said the minister had not considered his representations about the case.
"What I saw was a predetermined decision having been made. We were concerned in these details that really affect lives that there is proper compassion and fairness," he said.