Reny Jose, a mechanical engineering major and a member of Martel College at Rice University, was on a spring break at the time of his disappearance in the Panama City Beach, Florida.
The Bay County Sheriff's Office in Florida has been searching for him after Jose was last seen on Monday evening.
His friends told authorities that he went for a walk in the evening and never returned. He arrived to Panama City Beach on Saturday with his friends, News 10 reported.
Jose's clothing and personal items were found in a garbage can near the home, including his mobile phone.
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The family of the college student left for Panama City Beach to help with the search efforts.
"We were contacted yesterday by the Sheriff's Department notifying us that he was reported missing and that they were conducting search efforts," said Jismi George, Reny Jose's cousin.
A Sheriff's Office Air Unit has been covering the area and surrounding beaches.
"We're just pretty much working with what we have right now and that's not too much, so you know they're doing the best they can but obviously they are not doing too well," George said.
Incidentally, this is the third Indian-American student who has gone missing in the last few weeks, with their parents originally from Kerala.
Jasmine Joseph, 22, a nursing student from New York has been missing for over a week now.
Southern Illinois University student Pravin Varughese was found dead in Carbondale after missing for six days.