Mradulaben Patel from Gujarat, 59, was the co-owner of a store at a BP gas station in Powdersville. An unidentified man is believed to have shot Patel in the face on Thursday night. Police has asked for help to identify the assailant.
Patel, who underwent surgery on Friday, later succumbed to her injuries at the hospital.
Police said surveillance video footage shows a man walking into the store and buying a pack of cigars.
"I saw her lying there on the floor, bleeding pretty bad," said Wheat, adding that Patel had blood all over her head and on the floor.
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Wheat said he left the store and got in his truck from where he called emergency assistance number 911.
He said he ran back into the store without knowing whether or not the shooter had already left the scene of the incident.
Patel holds American and British citizenship.
"Our deepest condolences at the unfortunate demise of Ms. Mridulaben Patel, a PIO, after an attempted robbery at a gas station in S. Carolina," External Affairs Ministry Spokesperson Vikas Swarup tweeted.
The Indian Consulate in Atlanta has extended all possible assistance to the family of Patel and is in touch with police regarding the investigation, he said.
Officials of the Indian Consulate in Atlanta have spoken to her husband as well. However, sources said, Patel's family had not sought any assistance from the Indian mission.
"She always asked how everybody was, their day was, (and) she asked how my daughter was every day that I came in here," said Shalynn Zarczynski, a frequent customer of Patel's shop.
Two Indian-Americans -- Sanjay Patel (39) and Rajesh Madala (35) -- were killed during apparent robbery attempts in two separate incidents at gas stations in the US last month, sending shockwaves among the local population.