Veteran former national champions, Chetan Anand and Arvind Bhat, however failed to stretch their campaign at the Sydney Convention and Exhibition Centre.
Top seed Lee Chong Wei of Malaysia defeated Bhat 21-10 21-18 in 31 minutes while Indonesia's Riyanto Subagja got the better of Chetan Anand 21-14 21-16 in 25 minutes.
Among the ones who emerged victorious, Jayaram, seeded ninth, took less than an hour to thrash unseeded Malaysian Kwong Beng Chan 21-11 21-14 in their first ever encounter.
Jayaram and Pawar will next face South Korea's Dong Keun Lee and Malaysian Zulfadli Zulkiffli, respectively, in the next round.
Gurusaidutt, seeded 11th, took just about 15 minutes to cruch local boy Hu-Wen Chew 21-4 21-7.
Gurusaidutt will next meet Suppanyu Avihingsanon of Thailand in the next round.