The two women - who have been identified as Mersi, 41, from Nagaland and Mapathone Masne, 37, of South Africa - were arrested from Thamel by the anti-drug trafficking unit of the Nepal Police, who seized 2.7 kg of cocaine from their possession.
The duo had hidden the drugs in four shampoo bottles, according to Nepal Police.
They have been involved in the trafficking network extending from New Delhi, Kathmandu and Europe as well as South Africa for a long time, authorities said.
The have been taken into custody.