Laxmi would receive the award from US First Lady Michelle Obama at an awards ceremony at the State Department here.
She was 16 when an acquaintance threw acid on her face while she waited at a bus stop in New Delhi's busy Khan Market in 2005, disfiguring her permanently.
Her attacker, a friend's 32-year old brother, planned to use the acid to destroy Laxmi's face after she refused to respond to his romantic advances.
"She became the standard-bearer in India for the movement to end acid attacks. She made repeated appearances on national television, gathered 27,000 signatures for a petition to curb acid sales, and took her cause to the Indian Supreme Court," it said.
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"Laxmi's petition led the Supreme Court to order the Indian central and state governments to regulate immediately the sale of acid, and the Parliament to make prosecutions of acid attacks easier to pursue," the State Department said.
Secretary of State John Kerry, who was earlier scheduled to be present at the awards ceremony, is now travelling to Kiev in the aftermath of the Ukrainian situation. He would be represented by Deputy Secretary of State Heather A Higginbottom.
Last year, Nirbhaya, a courageous 23-year-old girl whose brutal gang rape on a moving bus in Delhi in December 2012, triggered widespread protests, received the prestigious award.
Established in 2007, the annual Secretary of State's International Women of Courage Award honours women around the globe who have exemplified exceptional courage and leadership in advocating for human rights, women's equality, and social progress, often at great personal risk.
This is the only Department of State award that pays tribute to emerging women leaders worldwide.
Among other awardees are Nasrin Oryakhil (Afghanistan), Roshika Deo (Fiji), Bishop Rusudan Gotsiridze (Georgia), Iris Yassmin Barrios Aguilar (Guatemala), Fatimata Toure (Mali), Maha Al Muneef (Saudi Arabia), Oinikhol Bobonazarova (Tajikistan), Ruslana Lyzhychko (Ukraine) and Beatrice Mtetwa (Zimbabwe).