Top seed Jayaram struggled past Canada's Martin Giuffre 17-21 21-17 21-13 in a 54-minute match to set up a fight with Austria's David Obernosterer.
Second seed H S Prannoy also made it to the pre-quarters after a hard-fought 13-21 21-11 21-15 win over Sweden's Mattias Borg in another men's singles match. He will next take on B R Sankeerth of Canada.
Commonwealth Games bronze medallist, RMV Gurusaidutt also stormed into the next round after an easy 21-8 21-6 win over local shuttler Jonathan Lai and will now face eighth seed Raul Must of Estonia next.
Young shuttler Pratul Joshi also registered a 21-13 21-12 win over Scotland's Alistair Casey and his next match will be against fellow Indian Harsheel Dani.
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In women's singles, 2015 National Champion Ruthvika Shivani Gadde defeated local player Kyleigh O' Donoghue 21-14 21-14. She will next face Austria's Elisabeth Baldauf.
Runners-up at 2016 Senior National championship, Tanvi Lad also made it to the prequarterfinals after defeating Denmark's Julie Finne-Ipsen 21-17 21-10 and will face Maya Chen of USA next.
Rio-bound Indian men's doubles pair of Manu Attri and B Sumeeth Reddy, top seeded, will face Canadian combo of Timothy Chiu and Jason Ho-Shue.