The Sanawad-bound bus from Indore collided with the van head-on and later overturned, Deputy Superintendent of Police J D Bhonsle said.
The deceased were identified as Dhananjay Mishra (40), Naren Pathak (55), Govardhan Malviya (55), Kaushalya bai (53) and Pooja (12).
The injured were admitted in various hospitals; the condition of two was said to be serious.