Yale did not disclose the amount gifted by Nooyi but said her "landmark gift" to endow the deanship of the school and inaugurate an innovation fund has made her the "most generous graduate" of Yale School of Management in terms of lifetime giving to the school.
She is also the first woman to endow the deanship at a top business school, the school said in a statement yesterday.
"Business issues are never just business issues, and my most ardent hope is that this endowment will teach future generations of leaders that the most successful companies of tomorrow will do more than make money," she said in a statement.
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Nooyi joins several prominent persons of Indian-origin who have donated generously to US universities.
In October last year, Nooyi's sister and Grammy-nominated musician Chandrika Tandon and her husband Ranjan had made a 100 million dollar gift to the New York University's School of Engineering, one of the largest philanthropic gifts by a member of the Indian-American community.
In 2010, Harvard Business School had received a gift of USD 50 million from Tata Companies.
Industrialist Ratan Tata had attended the School's Advanced Management Programme in 1975.
The fund is an ambitious initiative designed to advance the school's aim of developing leaders with the broad global mindset and multi-disciplinary approach to business that is needed to succeed in 21st-century capitalism.
It will be open to additional substantial contributions that can help the school develop the technology and other infrastructure to support these and future initiatives.