After falling 2.69 per cent to Rs 2,956.15 in intra-day trade, the stock of India's second largest software services firm ended at Rs 2,999.80, down 1.26 per cent on the BSE.
At the NSE, the IT major's scrip settled 1.35 per cent lower at Rs 3,000.
The exit of Thrikutam, who was also the head of Infosys Americas, comes within a fortnight of the resignation of President and Board Member B G Srinivas as the company searches for a CEO to succeed S D Shibulal who is due to retire by January next year.
This is the 11th top-level exit from the Bangalore-based company since the return of co-founder N R Narayana Murthy at the helm of affairs in June last year.
The firm in a statement had yesterday said: "Prasad Thrikutam has decided to pursue interests outside of Infosys. In his 19-year journey with the company, he has managed many portfolios including Hi-Tech Discrete Manufacturing Unit, Energy, Utilities & Services and most recently served at the Global Head of Strategic Sales, Marketing and Alliances."
President and Board Member U B Pravin Rao will manage Thrikutam's portfolios, Infosys had said.