The first of the four innovation centres for new technologies like artificial intelligence (AI) and machine learning will open in August in Indiana, the home state of US Vice-President Mike Pence.
Besides, Infosys Foundation USA will fund computer science training for over 1,000 public school teachers in the summer of 2017.
Infosys, which employs about two lakh people globally, is taking a number of steps, including setting up new centres, hiring locals and training people in the US, as part of concerted efforts to mitigate the impact of visa curbs there.
The move to hire more locals would also mean increase in labour costs for the company in the US.
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The location of the other three centres will be decided over the next few months, Sikka said, adding that these hubs will train people on technology and innovation.
The centres will also help in working closely with clients in key industries like financial services, manufacturing, healthcare, retail and energy.
The North American market accounted for over 60 per cent of Infosys' USD 10.2 billion revenue in 2016-17.
He said over the last three years, there has been an increase in the use of new technologies like AI and virtual reality and even the traditional projects are becoming highly automated.
"As work becomes more next-gen, you need a healthier mix of global and local talent and so, you need to rethink the traditional, what has historically been called 'global delivery model', and bring in a lot more talent locally," he added.
Over the past few weeks, there has been a growing sentiment of protectionism across various markets, including the US, that are seeking to safeguard jobs for locals and raising the bar for foreign workers.
In IT firms' defence, industry body Nasscom had said these two companies accounted for only 7,504 -- 8.8 per cent -- of the approved H-1B visas in 2014-15. At the end of March 2017, Infosys had over 2 lakh people on its payroll. Technology companies use work permits like H-1B visa (in the US) to send engineers to work on client sites.
Sikka, however, declined to comment on the investment and current mix of locals and global hires in the US.
Infosys -- which has over two lakh people on its payroll -- already hired over 2,000 people in the US in the last few years under Sikka.
The 10,000 people that will be hired will include experienced technology professionals and recent graduates from major universities, and local and community colleges.
Since 2015, Infosys has trained more than 134,000 students, over 2,500 teachers and almost 2,500 schools across America and provided classroom equipment through Infosys Foundation USA.
"The future is being written in code, and there is a critical need to invest in computer science education today... it is vital that students can identify and solve complex problems, develop critical thinking skills and learn the computational thinking," Infosys Foundation USA Chairperson Vandana Sikka said in a statement.
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