He takes over from Ashutosh Vaidya, who will move into a full-time position as head of Global Delivery for Dell Services.
Thrikutam, a 22-year industry veteran, will lead a global team of nearly 10,000 employees responsible for driving Dell's application services business across all vertical market segments, Dell said in a statement.
He will report to Dell Services President Suresh Vaswani and will be based at its headquarters in Plano, it added.
Prasad's strategic expertise and experience in driving industry-leading growth and margins across multiple verticals globally will help Dell continue to grow and help customers as they transform their business, he added.
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Thrikutam, whose exit from Infosys was announced yesterday, has quit the country's second largest software services firm after 19 years across multiple executive leadership roles. He was head of Infosys Americas and the global head for the USD 1.4 billion energy, utilities, telecom and services business unit.
"This is an important time for Dell as well as for the IT services industry. Our Application Services business that Prasad will lead presents a great opportunity for Dell as we help our customers modernise and take advantage of digital transformation opportunities," Chairman and CEO Michael Dell said.
He added that Prasad's addition to Dell's leadership is another example of the investments the company is making in growing the Services business.