The two-day conference reflects growing international alarm over the destruction of ancient artefacts by Islamic State group jihadists using sledgehammers, bulldozers and explosives.
Another key aim is to establish "refuge zones" around the globe for endangered works of art, according to organisers.
There were calls today by its Emirati, French and UN initiators for joint action to safeguard endangered cultural treasures.
"To succeed, we need to work together... United for heritage," UNESCO director Irina Bokova told participants.
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On the eve of the meeting, five Nobel prize winners appealed for urgent action to safeguard world heritage sites, pointing to irreparable damage in Iraq, Syria, Afghanistan and Mali.
"Part of our history has been lost forever, with the goal of fanaticism being to undermine our hope for the future," said the statement from Aung San Suu Kyi, Kofi Annan, Ellen Johnson Sirleaf, Orhan Pamuk and Mario Vargas Llosa.
The United Nations Educational, Scientific and Cultural Organization says 55 out of a total of 1,052 global heritage sites are listed as "World Heritage in Danger".
The conference aims to create "a broad coalition of partners connecting the dots between the security, humanitarian and cultural issues with so many organisations and governments" taking part, said Bokova.
Delegates from around 40 countries, including more than a dozen heads of state or government, among them several Gulf monarchs, are attending the gathering, based on an initiative led by France and the United Arab Emirates.