Amblyopia also known as lazy eye is the leading cause of monocular visual impairment in children.
It has traditionally been viewed as a monocular disorder that can be treated by patching the fellow (opposite) eye to force use of the amblyopic eye, but it does not always restore 20/20 vision or teach the eyes to work together.
Sinec amblyopia arises from binocular discordance, binocular treatments are likely to yield better vision outcomes.
However, it is unclear whether binocular treatment is comparable to patching in treating amblyopia.
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The action-oriented adventure iPad game required children to wear special glasses that separate game elements seen by each eye so that reduced-contrast elements are seen by the fellow eye, high-contrast elements are seen by the amblyopic eye and high-contrast background elements are seen by both eyes.
For successful game play, both eyes must see their respective game components. Children were asked to play the game at home for an hour a day, five days a week for two weeks making it a total of 10 hours.
The researchers found that at the two-week visit, improvement in amblyopic eye BCVA was greater with the binocular game compared with patching, with the average visual acuity improvement after binocular treatment being more than double the improvement found with patching.
This was achieved with less than 50 per cent treatment time required for patching - which is 28 hours.
Five of 13 children (39 per cent) with binocular treatment reached 20/32 or better visual acuity compared with one of 14 children (7 per cent) with patching.
At the four-week visit, no group difference was found in BCVA change, with children who crossed over to the binocular games catching up with children treated with binocular games.
"We show that in just two weeks, visual acuity gain with binocular treatment was half that found with six months of patching, suggesting that binocular treatment may yield faster gains than patching," researchers said.
"Whether long-term binocular treatment is as effective in remediating amblyopia as patching remains to be investigated," they said.