Netanyahu said Tehran's attempts to entrench itself along Israel's borders was one of the biggest emerging security threats facing the Jewish state.
"Alongside Iran's direct guidance of Hezbollah's actions in the north and Hamas's in the south, Iran is trying also to develop a third front on the Golan Heights via the thousands of Hezbollah fighters who are in southern Syria and over which Iran holds direct command," he said.
Speaking at the start of the weekly cabinet meeting, Netanyahu said his ministers were to be briefed on "the security challenges developing around us, first and foremost Iran's attempt to increase its foothold on Israel's borders even as it works to arm itself with nuclear weapons."
Israel neither confirmed nor denied responsibility, but it has carried out several such strikes over the past two years, stressing its policy of preventing arms transfers to militant groups and potential attacks.
Netanyahu said that Tehran's ongoing "murderous terrorism" has "not prevented the international community from continuing to talk with Iran about a nuclear agreement that will allow it to build the industrial capacity to develop nuclear weapons.