Ayatollah Ali Khamenei also called on critics of the interim nuclear deal achieved on November 24 in Geneva to be fair and give time to President Hassan Rouhani to pursue his policy of engagement with the outside world.
"The only solution to the country's economic problems is to employ (Iran's) infinite domestic capacities, not to pin hopes on the lifting of sanctions. No expectations from the enemy," Khamenei told army officers in Tehran.
The deal is the centrepiece of Rouhani's policy. Iran on Jan 20 stopped enriching uranium to 20 per cent and started neutralising its existing stockpile of that grade, just steps away from weapons material, in order to fulfil commitments reached under the interim deal.
The US and the European Union also lifted some sanctions, blamed for a sharp devaluation of the Iranian rial over the last two years, in response to the Iranian moves. The currency has recovered somewhat since Rouhani took office last summer.
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In return, the US and the EU simultaneously announced the lifting of sanctions on petrochemical products, insurance, gold and other precious metals, auto industry, passenger plane parts and services.
They also plan to release USD 4.2 billion Iranian assets of oil revenues blocked overseas, in eight instalments over a period of six months. The first instalment of USD 550 million was provided to Iran on Feb 1, according to Iranian officials.
Rouhani and his foreign minister, Mohammad Javad Zarif, have a tough task selling the accord to sceptics. Iran's hard-liners call the deal a "poisoned chalice," saying Rouhani made too many concessions in return for too little.
Prominent hard-liner Ayatollah Mohammad Taqi Mesbah Yazdi earlier this week accused the president of selling Iran's "dignity" under the Geneva deal.
But Khamenei defended Rouhani and urged critics to be patient and fair.