The trade-off would allow Iran to run several hundred of the devices at its Fordo facility, although the Iranians would not be allowed to do work that could lead to an atomic bomb and the site would be subject to international inspections, according to Western officials familiar with details of negotiations now underway.
In return, Iran would be required to scale back the number of centrifuges it runs at its Natanz facility and accept other restrictions on nuclear-related work.
The number of centrifuges would not be enough to produce the amount of uranium needed to produce a weapon within a year the minimum time-frame that Washington and its negotiating partners demand.
The officials spoke only on condition of anonymity because they were not authorized to discuss details of the sensitive negotiations as the latest round of talks began between US Secretary of State John Kerry and Iranian Foreign Minister Mohammed Javad Zarif.
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One senior US official declined to comment on the specific proposal but said the goal since the beginning of the talks has been "to have Fordo converted so it's not being used to enrich uranium."
That official would not say more.
The officials stressed that the potential compromise on Fordo is just one of several options on a menu of highly technical equations being discussed in the talks.
Experts say the compromise for Fordo could still be problematic.
They note it would allow Iran to keep intact technology that could be quickly repurposed for uranium enrichment at a sensitive facility that the US and its allies originally wanted stripped of all such machines centrifuges that can spin uranium gas into uses ranging from reactor fuel to weapons-grade material.