"Iran is the cause of the problem, Iran continues to support the Huthis, Iranian arms are smuggled. Iran is part of the problem, not the solution," Foreign Minister Abdulmalik al-Mekhlafi said when asked if Tehran could contribute to a political solution in Yemen.
He was speaking at UN headquarters after a major luncheon hosted by Yemen and Saudi Arabia with the majority of diplomatic missions to the United Nations.
Saudi humanitarian aid to Yemen is estimated to top 8.2 billion dollars.
The Saudi-led military coalition largely controls the country's airspace, although US drones also carry out strikes on suspected Al-Qaeda bases there.
More than 8,300 people have been killed and 44,000 wounded since the Saudi-led coalition entered the Yemen war in 2015.
Close to 2,000 Yemenis have also died of cholera since April and another 600,000 are expected to contract the infection this year.