"I believe this effort is fruitless and it should not be an impediment to an agreement," Iranian Foreign Minister Mohammad Javad Zarif said at a joint press conference with his visiting Italian counterpart Paolo Gentiloni.
"It is unfortunate that there is a group which sees its interests in tension and crisis."
Netanyahu's bid was "an attempt to utilise a fabricated crisis to cover up realities in the region, including occupation, the suppression of Palestinians and the violation of their rights", he said.
Netanyahu will travel next week to Washington to denounce a possible agreement in the Iranian nuclear talks, which he considers contrary to the interests of Israel.
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The Israeli leader said Wednesday that his speech before Congress was part of his "duty" to protect the Jewish state's security.
"Under the agreement that is being prepared, we have reason to worry ... If the world powers have apparently found common ground with Iran," he said.
The so-called P5+1 group of Britain, China, France, Russia, the United States and Germany are trying to strike an accord that would prevent Tehran from developing a nuclear bomb.
In return, the West would ease punishing sanctions imposed on Tehran over its nuclear programme, which Iran insists is purely civilian.
A March 31 deadline for a political framework for the deal is looming with negotiators saying they will aim to pin down the final technical details by June 30.