Such protests take place every year outside the compound that once housed the embassy on the anniversary of the 1979 takeover that followed the Islamic Revolution in Iran.
Iranians at the rally outside the former embassy building on Thursday chanted "Death to America" and "Death to Israel" and burned the US and Israeli flags.
On November 4, 1979, Iranian militant students stormed the US Embassy, taking 52 Americans hostage for 444 days after Washington refused to hand over Iran's toppled shah, Mohammad Reza Pahlavi, for trial in Iran.