The chants, customary after Friday services in the Iranian capital, reflect the challenges facing President Hassan Rouhani as he tries to build on the groundbreaking exchanges with Washington that included a telephone chat last week with President Barack Obama a gesture aimed at ending three decades of estrangement between the two countries.
Rouhani's overtures have been hailed by both Iranian reformists and the country's conservative clerical leadership.
During prayers today in Tehran, the master-of-ceremonies led the crowd into chants of "Death to America" at least twice from the podium.
The chant was then repeated several times by a group of worshippers who rallied after the ceremony, burning the American and Israeli flags, as they do almost every week.
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However, Ayatollah Kazem Sedighi, a cleric who led the prayers, tried to strike middle ground, saying that America and Iran should "join hands" in a struggle to overcome sanctions that have crippled Iran's economy.
Though Sedighi said Iran would not pull back from its "peaceful nuclear rights," he expressed hope that Rouhani's policies would "save the region and the world from a dead-end and a crisis."
Iran has faced repeated rounds of UN sanctions over its disputed nuclear program, which the West suspects is geared toward producing an atomic weapon. The country is also living under tough US-led oil and banking sanctions that have slashed oil exports by half and shut Tehran out of the international financial system.
In a visit to New York for the UN General Assembly last week, Rouhani agreed to restart nuclear talks with the five permanent members of the Security Council plus Germany in Geneva later this month.
Another speaker today, Mohammad Hossein Saffar Harandi who is part of an advisory council to the Supreme Leader Ayatollah Ali Khamenei, said the US decided to work things out with Iran through diplomacy because of the crisis it faces over Syria's conflict.
"But, honestly, we also need them," Harandi said, referring to Americans. "We would like to have an opening that would remove these oppressive sanctions.